An Improved Method of the Total Microcystin Determination using Reversed-phase Liquid Chromatography Mass Spectrometry
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چکیده
منابع مشابه
Determination of Trazodone in Human Plasma by Reversed-phase Liquid Chromatography-mass Spectrometry with Electrospray Ionisation
Objective: The development and validation of LC-MS/MS method for quantification of Trazodone (a serotonin antagonist and reuptake inhibitor (SARI), which is a second generation antidepressant compound belonging to the class of phenyl piperazine) in human plasma is described. Methods: The method involves protein precipitation (extraction) using Trazodone d6 as an internal standard (IS). Chromato...
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A convenient liquid chromatographic-single Quadrupole mass spectrometric (LC-MS) method was developed and validated for dexchlorpheniramine maleate (INN name: chlorphenamine) determination in human plasma. The need for just a single liquid-liquid extraction with ethyl acetate and being highly sensitive were the advantages of this method. The linearity was also excellent over the range of 1...
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Reversed-phase HPLC coupled to the atmospheric pressure ionization-electrospray ionization (API-ESI) MS was used for microcystin-LR detection and quantitation in samples of dried Microcystis aeruginosa cells. An alkaline linear gradient (20 mmol/l ammonium hydroxide-acetonitrile, pH 9.7) was used for elution of the toxic peptides. Limit of detection was 1 microg/ml (20 ng per injection) in the ...
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The molluscicide metaldehyde (2,4,6,8-tetramethyl-1,3,5,7-tetraoxocanemetacetaldehyde) is an emerging pollutant. It is frequently detected in surface waters, often above the European Community Drinking Water Directive limit of 0.1 μg/L for a single pesticide. Gas chromatography mass spectrometry (GC-MS) can be used to determine metaldehyde in environmental waters, but this method requires time ...
متن کاملReversed-phase liquid chromatography and gas chromatography/mass fragmentography compared for determination of tricyclic antidepressant drugs.
We compare measurement of the tricyclic antidepressants desipramine, imipramine, nortryptaline, and amitryptaline by reversed-phase "high-performance" liquid chromatography and by gas chromatography/mass fragmentography. The liquid-chromatographic procedure does not require ion-pairing reagents, and involves detection at 215 nm. The within-day and between-day CVs for this method were less than ...
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ژورنال
عنوان ژورنال: Journal of Environmental Chemistry
سال: 2004
ISSN: 1882-5818,0917-2408
DOI: 10.5985/jec.14.587